Gonadotropin chorionic
Gonadotropin, chorionic is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target lutropin-choriogonadotropic hormone receptor.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Chorionic gonadotropin, Novarel (discontinued: A.p.l, Chorionic gonadotropin, Novarel)
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Chorionic gonadotropin
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Novarel | chorionic gonadotropin | Ferring Pharmaceuticals | N-17016 RX | 1974-01-15 | 1 products |
| Chorionic Gonadotropin | chorionic gonadotropin | Fresenius Kabi | N-17067 RX | 1973-03-05 | 1 products |
Show 4 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| chorionic gonadotropin | Biologic Licensing Application | 2020-04-02 |
| novarel | Biologic Licensing Application | 2024-04-24 |
| pregnyl | Biologic Licensing Application | 2024-06-21 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| female infertility | EFO_0008560 | D007247 | N97 |
| hypogonadism | HP_0000044 | D007006 | E23.0 |
| cryptorchidism | EFO_0004562 | D003456 | Q53.1 |
Agency Specific
FDA
EMA
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No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
584 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | HP_0000789 | — | 13 | 21 | 32 | 65 | 93 | 214 |
| Female infertility | D007247 | EFO_0008560 | N97 | 5 | 5 | 4 | 8 | 22 | 41 |
| Syndrome | D013577 | — | — | 3 | 4 | 7 | 8 | 19 | 39 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 6 | 5 | 9 | 6 | 15 | 37 |
| Fertilization in vitro | D005307 | — | — | 1 | 3 | 5 | 8 | 12 | 28 |
| Hypogonadism | D007006 | HP_0000044 | E23.0 | 1 | 2 | 4 | 6 | 6 | 19 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | 2 | 2 | 1 | 14 | 18 |
| Ovulation induction | D010062 | — | — | 2 | 4 | — | 1 | 8 | 15 |
| Embryo transfer | D004624 | — | — | 1 | 1 | 1 | 3 | 9 | 15 |
| Assisted reproductive techniques | D027724 | — | — | 1 | — | 3 | 1 | 5 | 10 |
Show 33 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | 5 | 1 | — | 2 | 8 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | 3 | 2 | — | 2 | 6 |
| Induced abortion | D000028 | — | — | — | — | 1 | — | 5 | 6 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 2 | 1 | — | 3 | 6 |
| Gestational trophoblastic disease | D031901 | — | O01.9 | — | — | 2 | — | 3 | 5 |
| Trophoblastic neoplasms | D014328 | — | — | — | — | 2 | — | 3 | 5 |
| Communicable diseases | D003141 | — | — | 1 | 4 | 1 | — | — | 5 |
| Covid-19 | D000086382 | — | — | 1 | 3 | 1 | — | — | 5 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | 1 | — | 1 | 4 |
| Hiv | D006678 | — | — | — | 1 | 1 | — | 2 | 4 |
Show 24 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | 2 | — | — | 3 | 7 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 3 | — | — | 1 | 5 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 4 | — | — | 1 | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 3 | 4 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | 3 | 4 |
| Ischemic stroke | D000083242 | — | — | — | 3 | — | — | 1 | 4 |
| Plasma cell neoplasms | D054219 | — | — | 1 | 1 | — | — | 1 | 3 |
| Premature menopause | D008594 | HP_0008209 | E28.31 | 1 | 1 | — | — | 2 | 3 |
| Azoospermia | D053713 | EFO_0000279 | N46.0 | 1 | 1 | — | — | 1 | 3 |
| Graft vs host disease | D006086 | — | D89.81 | 3 | 2 | — | — | — | 3 |
Show 42 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperandrogenism | D017588 | — | — | 2 | — | — | — | 1 | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | 1 | 2 |
| Fibrosis | D005355 | — | — | 1 | — | — | — | 1 | 2 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | — | — | — | 1 | 2 |
| Spondylarthritis | D025241 | — | — | 1 | — | — | — | 1 | 2 |
| Spondylitis | D013166 | — | M46.9 | 1 | — | — | — | 1 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | 1 | 2 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | — | — | — | — | 1 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | 1 | — | — | — | — | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | 1 | — | — | — | — | 1 |
Show 15 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy tests | D011258 | — | — | — | — | — | — | 5 | 5 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | — | 4 | 4 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | — | — | 3 | 3 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 3 | 3 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 3 | 3 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | — | — | — | 3 | 3 |
| Melanoma | D008545 | — | — | — | — | — | — | 2 | 2 |
| Corpus luteum maintenance | D003340 | — | — | — | — | — | — | 2 | 2 |
| Premature obstetric labor | D007752 | — | O60 | — | — | — | — | 2 | 2 |
| Eunuchism | D005058 | EFO_0007266 | E29.1 | — | — | — | — | 2 | 2 |
Show 132 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Gonadotropin chorionic |
| INN | — |
| Description | Choriogonadotropin beta chain [Precursor]; Glycoprotein hormones alpha chain [Precursor]; |
| Classification | Protein |
| Drug class | atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201509 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
Target
Agency Approved
No data
Alternate
LHCGR
LHCGR
Organism
Homo sapiens
Gene name
LHCGR
Gene synonyms
LCGR, LGR2, LHRHR
NCBI Gene ID
Protein name
lutropin-choriogonadotropic hormone receptor
Protein synonyms
hypergonadotropic hypogonadism, LHR, LSH-R, Luteinizing hormone receptor, lutropin/choriogonadotropin receptor
Uniprot ID
Mouse ortholog
Lhcgr (16867)
lutropin-choriogonadotropic hormone receptor (P30730)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
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No Black-box warning
Adverse Events
Top Adverse Reactions
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2,170 adverse events reported
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